Medical University of South Carolina (MUSC) intends to award a single source purchase order to Scientific Volume Imaging BV., for the acquisition of the Huygens Image Decovoluton and Restoration Software Suite to provide super-resolution deconvolution of images collected with an existing Zeiss LSM 880 Airyscan microscope. This deconvolution improves the resolving power of the Zeiss microscope system. The super-resolution deconvolution software must be compatible with the Zeiss LSM 880 Microscope.

The MUSC Advanced Cell Imaging Core, which serves as the Cell & Molecular Imaging (CMI) Shared Resource for the Hollings Cancer Center, provides MUSC investigators with training, assistance and access to high-end light microscopes of different configurations and capabilities. The goal of microscopy is to resolve the smallest possible structures, which is limited by the intrinsic resolving power of the particular microscope being used. Our best resolving microscope system is the Zeiss LSM 880 Airyscan microscopy. The requested Huygens Image Deconvolution and Restoration Software will improve the resolving power of the Zeiss system by a factor of at least 1.5 in each direction (x, y and z) and by at least 3-fold in all directions. Thus, the requested software will allow our investigators to visualize small structures that cannot be visualized with existing equipment to better achieve their research objectives.